REVLIMID is a daily oral capsule, not a traditional chemotherapy, that is only available through a special distribution program called Lenalidomide REMS. If you experience any side effects while taking REVLIMID, tell your doctor right away.
Before you take REVLIMID, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. REVLIMID and other medicines may affect each other, causing serious side effects. Talk with your healthcare provider before taking any new medicines. Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist.
Every patient who takes REVLIMID® (lenalidomide) must enroll in the Lenalidomide Risk Evaluation and Mitigation Strategy (REMS) program before they can begin receiving REVLIMID. See the Lenalidomide REMS page for more information.
Download our free REMS Companion App to help you complete your monthly REMS survey.
If you miss a dose of REVLIMID and it has been less than 12 hours since your regular time, take it as soon as you remember. If it has been more than 12 hours, skip your missed dose. Do not take 2 doses at the same time. Please see accompanying full Prescribing Information, including Boxed WARNINGS and Medication Guide, and Important Safety Information.
Keep REVLIMID and all medicines out of reach of children.
Tell your healthcare team immediately about any side effects you are experiencing, and do not stop taking REVLIMID unless directed. Your doctor can adjust your dose to help reduce side effects. In the case of a severe side effect, your doctor may tell you to discontinue treatment.
A stem cell transplant (SCT) is effective in helping patients with multiple myeloma significantly reduce myeloma cells and restore the bone marrow’s ability to produce healthy blood cells. But after an SCT, 100 million myeloma cells can remain in your body, even with a complete response. Many doctors recommend maintenance therapy following an SCT because it plays an important part in extending the response from a transplant as long as possible.
If you have had an autologous hematopoietic stem cell transplant (auto-HSCT), you might want to ask your doctor about REVLIMID maintenance therapy. Maintenance therapy is a proven strategy to extend the response from an SCT. Maintenance therapy may control the growth of residual myeloma cells. An SCT is effective in helping multiple myeloma patients significantly reduce myeloma cells and restore the bone marrow’s ability to produce healthy blood cells. Many doctors recommend maintenance therapy following an SCT because it plays an important part in extending the response from a transplant as long as possible. So you can both make an informed decision, ask your doctor for more information about REVLIMID maintenance therapy.
In clinical trials, patients took REVLIMID maintenance therapy every day, until their disease progressed or they experienced intolerable side effects. In studies, low white blood cells (neutropenia) and low platelets (thrombocytopenia) were the most common adverse events that led to discontinuation of REVLIMID maintenance therapy in a small percentage (less than 3%) of patients.
The standard dosing for maintenance therapy with REVLIMID is one 10-mg pill, taken once every day by itself (without dexamethasone). If tolerated, your doctor may increase your dose to 15 mg of REVLIMID once daily.
Study 1 and Study 2 were both designed to evaluate the safety and effectiveness of REVLIMID as maintenance therapy after a stem cell transplant, but there were many differences in how the studies were conducted. Some differences between the studies include:
These are not all of the differences between the studies. Talk to your doctor to understand what the study results may mean for you.