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This site is intended for US audiences only.

REVLIMID is a prescription medicine used to treat people with mantle cell lymphoma (MCL) when the disease comes back or becomes worse after treatment with two prior medicines, one of which included bortezomib. MCL is a cancer of a type of white blood cell called lymphocytes that are in the lymph nodes.
REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children.

Mantle cell lymphoma

Mantle cell lymphoma is a cancer that occurs when a type of white blood cell called a lymphocyte becomes cancerous and multiplies out of control.
Mantle cell lymphoma gets its name from where it forms in the outer edge of the lymph node, known as the mantle zone. The body has 3 main types
of lymphocytes, B cells, T cells, and natural killer (NK) cells, all of which are part of the immune system:

B cells (lymphocytes)
B Cells

Help protect the body against bacteria and viruses by making antibodies that help the immune system recognize these pathogens and allow T cells to attack them.

T cells (lymphocytes)
T Cells

The 2 major types of T cells are helper T cells and cytotoxic T cells. Helper cells assist other cells in the immune system. Cytotoxic T cells attack cells infected by pathogens.

NK cells (lymphocytes)
NK Cells

NK cells are a type of immune cell
that can attack tumor cells or
cells infected with a virus.

The 2 main groups of lymphoma types are called Hodgkin lymphoma and non-Hodgkin lymphoma, usually abbreviated as NHL. Mantle cell lymphoma is a relatively rare form of NHL. Of the more than 74,000 new cases of NHL per year, only about 6% are mantle cell lymphoma. Mantle cell lymphoma occurs more frequently in older adults (early 60s), and it is more often diagnosed in men than in women. Mantle cell lymphoma may be “aggressive” (fast growing), but it may be “indolent” (slow growing) in some patients. The disease can be found in many parts of the body, including the lymph nodes, spleen, bone marrow, and other organs throughout the lymphatic system, which is a part of the body’s immune system.

Potential signs and symptoms of mantle cell lymphoma

  • loss of appetite
  • weight loss
  • fever
  • night sweats
  • nausea and/or vomiting
  • indigestion
  • abdominal pain or bloating
  • discomfort due to enlarged
    tonsils, liver, or spleen
  • lower back pain that can
    extend down one or both legs
  • fatigue due to developing anemia
Hypothetical REVLIMID® (lenalidomide) patient with MCL (mantle cell lymphoma) being examined by their doctor
Hypothetical doctor talking to a REVLIMID® (lenalidomide) patient with MCL (mantle cell lymphoma) while showing them their tablet

Diagnosis of mantle cell lymphoma

Mantle cell lymphoma is diagnosed by examining the affected tissue obtained from a surgical biopsy, usually of a lymph node.

Diagnosis may also include blood tests, CT scans, and PET scans, as well as an endoscopy or colonoscopy.