This site is intended for US audiences only.

This site is intended for US audiences only.

REVLIMID is a prescription medicine used to treat adults with follicular lymphoma (FL) or marginal zone lymphoma (MZL) in combination with a rituximab product, and who have previously been treated for their FL or MZL. FL and MZL are types of cancer of white blood cells called B-cell lymphocytes that are found in the lymph nodes and spleen. REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children.

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Lenalidomide REMS program.

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R2 helped extend the amount of time without
FL or MZL getting worse vs rituximab alone

R2 was studied in a pivotal clinical trial

Patients received R2 for up to 12 cycles. R2 was studied in 358 patients with follicular lymphoma or marginal zone lymphoma who had received at least 1 prior treatment. Patients were separated into 2 groups, those receiving R2 and those receiving rituximab. The primary goal of the study was to see how long patients lived without the disease getting worse.


R² (REVLIMID® [lenalidomide] + rituximab) logo
  • 178 patients received the combination of REVLIMID + rituximab

  • REVLIMID was given for up to 12 months

  • Rituximab was given for 5 months

rituximab logo
  • 180 patients received only rituximab

  • Rituximab was given for 5 months

Patients receiving R2 had more time without their disease
getting worse than patients who received rituximab only

The benefits of R2 may continue after the treatment period ends (see data below).

Chart showing R² (REVLIMID® [lenalidomide] + rituximab) clinical trial data


median* time without
disease worsening

Patients in the R2 group experienced side effects such as low blood cell counts, diarrhea, constipation, cough, fatigue, rash, fever, and itching more frequently than patients in the rituximab group.

Learn about the side effects of R2.

*In a series of numbers, the median is the number in the exact middle, e.g., if the sequence is 0-10, 5 is the median.