This site is intended for US audiences only.

This site is intended for US audiences only.

REVLIMID is a prescription medicine used to treat adults with follicular lymphoma (FL) or marginal zone lymphoma (MZL) in combination with a rituximab product, and who have previously been treated for their FL or MZL. FL and MZL are types of cancer of white blood cells called B-cell lymphocytes that are found in the lymph nodes and spleen. REVLIMID should not be used to treat people who have chronic lymphocytic leukemia (CLL) unless they are participants in a controlled clinical trial. It is not known if REVLIMID is safe and effective in children.

The REMS Companion App

Easily access the
Lenalidomide REMS program.

Download now

The role of your immune system

Hypothetical doctor going over a file with a R² (REVLIMID® [lenalidomide] + rituximab) patient with relapsed/refractory follicular or marginal zone lymphoma

What is the immune system?

The immune system is a combination of organs and cells that protect the body from infection and other diseases by fighting harmful pathogens. The immune system includes white blood cells, lymph nodes, the spleen, bone marrow, and other organs and tissues.


Lymphocytes are a type of immune cell that’s made in the bone marrow and found in the blood and in lymph tissue.
Three types of lymphocytes are B cells, T cells, and natural killer (NK) cells. Lymphocytes are also called white blood cells.

B cell
B Cells

Help protect the body against bacteria and viruses by making antibodies that help the immune system recognize these pathogens and allow T cells to attack them.

T cell
T Cells

The 2 major types of T cells are helper T cells and cytotoxic T cells. Helper cells assist other cells in the immune system. Cytotoxic T cells attack cells infected by pathogens.

NK cell
NK Cells

NK cells are a type of immune cell
that attack tumor cells or
cells infected with a virus.

The function of a healthy immune system

When the immune system is healthy, it protects the body not only from infection, but can also identify cancerous and/or precancerous cells and eliminate them before they can cause harm, in a process called immune surveillance. Immune cells responsible for attacking cancer cells include T cells and NK cells.

Hypothetical doctor smiling and holding the shoulders of a R² (REVLIMID® [lenalidomide] + rituximab) patient with relapsed/refractory follicular or marginal zone lymphoma

The impact of immune dysfunction

When the immune system doesn’t function optimally due to lymphoma, T cells and NK cells can fail to either detect or destroy the cancerous cells, including non-Hodgkin’s lymphoma (NHL) cells. Cancer cells also promote preferential growth of regulatory T cells, suppressing T cell activity and resulting in further immune dysfunction.